APP divergent transcript (APP-DT)

The APP divergent transcript (APP-DT) is a long non-coding RNA, meaning it does not encode a protein. It is transcribed from the *APP* locus on chromosome 21 in the direction opposite to the canonical *APP* gene. Divergent transcripts such as APP-DT are generated from promoters that yield non-coding, often unstable RNAs oriented antisense to nearby protein-coding genes[1][5][7]. There is currently limited characterization of APP-DT's function, and it is not a receptor, enzyme, or established therapeutic target. Its relevance, if any, is likely to be in gene regulation or maintaining chromatin structure, as is broadly suggested for other divergent lncRNAs, though no direct functional evidence for APP-DT exists[2][6][5].

Not applicable; there are no drugs or inhibitors known to target this transcript