Target intelligence / Profile preview

Aquaporin (AQP)

Target: AQP
Molecular classification: Integral membrane protein, Water channel, Aquaglyceroporin (for some subtypes)

Overview

Aquaporins are a family of integral membrane proteins that facilitate the rapid and selective transport of water across cell membranes. They are essential for maintaining water homeostasis in various tissues and are implicated in several diseases. Some subtypes also transport small solutes like glycerol.

Other names: Water channel protein

Mechanism of action

Inhibition of water transport

Biological functions

Water transportCell volume regulationGlandular secretionUrine concentrationBrain fluid balanceSkin hydrationSolute transport (for aquaglyceroporins)

Disease associations

Nephrogenic diabetes insipidusEdemaBrain edemaGlaucomaCancerSkin disorders

Safety considerations

Off-target effects due to wide tissue distributionPotential disruption of fluid balance

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