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Aquaporin-1 (AQP1)
- Target
- AQP1
- Molecular classification
- Aquaporin, Major Intrinsic Protein (MIP), Transporter, Ion Channel (cGMP-gated)
01
Overview
Aquaporin-1 (AQP1) is a water channel protein that facilitates the rapid transport of water across cell membranes. It forms a homotetramer, with each monomer acting as an independent pore. AQP1 is highly expressed in the kidney, red blood cells, vascular endothelium, and other tissues, where it plays a crucial role in maintaining water balance. It also functions as a non-selective cation channel when gated by cGMP. Dysregulation of AQP1 is associated with various diseases, including nephrogenic diabetes insipidus and certain types of edema.
- Other names
- Aquaporin 1Water channel protein 1CHIP28COAQP-1
02
Mechanism of action
Facilitates rapid passive transport of water and certain small solutes across cell membranes; non-selective cation channel when gated by cGMP.
03
Biological functions
Water transportRegulation of cell volumeUrine concentrationCerebrospinal fluid productionAngiogenesisFibroblast proliferationSaliva secretion
04
Disease associations
Nephrogenic diabetes insipidusEdemaGlaucoma (potentially)Colton blood group system (antigen)Cancer
05
Safety considerations
Disruption of fluid homeostasisPotential role in tumor angiogenesis and metastasis
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