Target intelligence / Profile preview

Aquaporin-1 and Aquaporin-3 (AQP1 and AQP3)

Target: AQP1 and AQP3
Molecular classification: Transporter, Water Channel

Overview

Aquaporin-1 and Aquaporin-3 are water channels that facilitate the rapid transport of water across cell membranes. These proteins are crucial for maintaining water balance in various tissues, including the kidneys and brain. Their dysregulation is associated with several diseases, such as diabetes insipidus and cerebral edema.

Other names: Water Channels

Mechanism of action

Modulation of water permeability across cell membranes

Biological functions

Water transportOsmoregulationCell migration

Disease associations

Diabetes InsipidusCerebral EdemaCongenital Cataracts

Safety considerations

Potential for cerebral edema with dysregulation of AQP4; other concerns are less specific to AQP1 and AQP3.

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