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Aquaporin-11 (AQP11)
- Target
- AQP11
- Molecular classification
- Transporter, Channel protein, Aquaporin family (subfamily: AQP11/AQP12-type)
01
Overview
Aquaporin-11 is an intracellular member of the aquaporin family with distinct sequence features, including a conserved C-terminal NPA motif and a unique N-terminal NPC (Asn-Pro-Cys) motif. Unlike classical plasma membrane aquaporins, AQP11 localizes primarily to the endoplasmic reticulum and possibly other intracellular membranes, where it facilitates water, glycerol, and hydrogen peroxide transport, contributing to organ homeostasis, protein folding, redox balance, and development. In the kidney, AQP11 is essential for proximal tubule function and postnatal renal development; mice lacking AQP11 rapidly develop fatal renal cysts and failure. Its channel activity helps maintain homeostasis under physiological and stress conditions, including ER oxidative stress responses. While its dysfunction is linked to specific renal diseases and skin disorders, AQP11 is not a current therapeutic target, and no drugs are available that directly modulate its activity.
- Other names
- AQP11AQPX1PSEC0027AQP-11aquaporin-11
02
Mechanism of action
Not applicable (no drugs currently target this protein)
03
Biological functions
Water channel activityGlycerol channel activityHydrogen peroxide (H₂O₂) channel activityIntracellular water homeostasisEndoplasmic reticulum redox regulationRenal tubular development and functionSpermatogenesisProtein folding and glycosylation in ER
04
Disease associations
Renal cystic disease/renal failure (AQP11-null mice die from neonatal renal failure)Palmoplantar keratoderma, Bothnian typeRenal Wilms' tumor (reported association)Other potential roles in organ development
05
Safety considerations
No drug safety concerns reported; mutations or loss of function causes severe renal developmental defects in animal models
06
Interacting drugs
None currently approved or widely reported as directly interacting with AQP11
07
Biomarkers
None validated for clinical use; expression changes in renal disease may offer future potential
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