Aquaporin 7 pseudogene 1 (AQP7P1)

Aquaporin 7 pseudogene 1 (AQP7P1), annotated as ENSG00000277737, is a human pseudogene related to the aquaporin family, specifically to Aquaporin 7 (AQP7). Pseudogenes like AQP7P1 are genomic sequences similar to known genes but are typically non-functional due to mutations or truncations that prevent them from producing a functional protein. AQP7P1 is not known to encode a functional membrane channel, to serve as a therapeutic target, or to play a direct biological or disease role[2][3].\n\nClarification:\n- is_incorrect: true. This entry is not a therapeutic target because it is a pseudogene, not a functional gene product like a receptor, transporter, or enzyme[2].\n- Confusion may arise because the protein-coding AQP7 gene (Aquaporin 7) is a biologically functional transporter involved in glycerol and water movement, but ENSG00000277737 (AQP7P1) is a distinct, non-coding pseudogene[1][3].\n- Aquaporin 7 pseudogene 1 has no established role as a drug target, no known interacting drugs, no mechanism of action relevant to therapy, and is not a biomarker.\n\nThis distinction is important: while aquaporins are a functionally important family and some (like AQP7) have been studied for their biological and potential clinical roles, the pseudogenes in this family are non-functional genomic relics[2][3].

Other names

BA251O17.3