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Target intelligence / Profile preview
Aquaporin Channel (Colon) (AQP (Colon))
- Target
- AQP (Colon)
- Molecular classification
- Integral membrane protein, Water channel, Aquaporin
01
Overview
Aquaporin channels (AQPs) are integral membrane proteins that facilitate water transport across cell membranes. In the colon, AQP3 is the predominant subtype, but AQP4 and AQP8 also contribute. These channels regulate water absorption and secretion, crucial for intestinal fluid homeostasis and fecal consistency. Altered AQP expression or function is implicated in constipation and diarrhea, making them potential therapeutic targets. Regulation occurs via hormones, intestinal contents, and inflammatory mediators.
- Other names
- Water channel protein (Colon)AQP3 (Colon)AQP4 (Colon)AQP8 (Colon)
02
Mechanism of action
Inhibition of water absorption; Enhancement of water absorption
03
Biological functions
Water transportFluid homeostasisElectrolyte balanceRegulation of fecal consistencyWater absorptionWater secretion
04
Disease associations
ConstipationDiarrheaGastrointestinal disorders
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