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Target intelligence / Profile preview
Aquaporin Family Protein (AQP)
- Target
- AQP
- Molecular classification
- Integral Membrane Protein, Water Channel, Aquaporin
01
Overview
The aquaporin family proteins are essential membrane channels responsible for controlled cellular movement of water—and sometimes small solutes—across biological membranes. Their unique structure underlies their high specificity and efficiency. With broad distribution across tissues and organisms plus significant clinical implications when mutated or dysregulated, they remain key subjects in physiology research and drug development efforts targeting disorders involving fluid imbalance or edema formation.
02
Mechanism of action
Modulation of aquaporin activity or expression
03
Biological functions
Water transportGlycerol transport (in some subtypes)Maintaining cellular water homeostasisUrine concentrationGlandular secretionBrain fluid balancePlant transpiration
04
Disease associations
Nephrogenic diabetes insipidusBrain edemaCataracts
05
Safety considerations
Off-target effects on other aquaporin subtypesDisruption of electrolyte balance
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