Ara h 6 seed storage protein (2S albumin) (Ara h 6)

Ara h 6 is a heat-stable, protease-resistant seed storage protein found in peanuts (Arachis hypogaea), classified as a *2S albumin* and member of the prolamin superfamily[1][3][4][5]. It is highly immunogenic, often triggering strong IgE-mediated allergic reactions in susceptible individuals[1][3][5][6]. Ara h 6 shares substantial amino acid homology and cross-reactivity with Ara h 2, another major peanut allergen[1][2][3][5][6]. Its structural stability makes it resistant to food processing and digestion, contributing to the risk of severe systemic reactions such as anaphylaxis[1][2][3][4][5][6][8]. The protein is used in clinical diagnostics; detecting IgE antibodies to Ara h 6 helps identify patients at risk for severe peanut allergy[1][5][7][8]. Circulating Ara h 6 may also serve as a biological marker for exposure and absorption[7]. There are no direct drugs targeting Ara h 6, and management relies on interventions that modulate immune response to its allergenic activity[1][3][5][8].

Other names

Ara h 6Peanut allergen Ara h 62S albumin Ara h 6Seed storage protein Ara h 6