Target intelligence / Profile preview

Arabinosyl transferase III (EmbB)

Target: EmbB
Molecular classification: Enzyme, Glycosyltransferase

Overview

Arabinosyl transferase III (EmbB) is a membrane-bound glycosyltransferase enzyme in Mycobacterium tuberculosis, critical for polymerizing arabinose into arabinogalactan, an essential cell wall component. It is a primary target for ethambutol, a first-line anti-tuberculosis drug. Mutations in embB, particularly near codon 306, are associated with ethambutol resistance.

Other names: EmbB protein

Mechanism of action

Inhibition of arabinosyl transferase activity

Biological functions

Arabinose polymerizationArabinogalactan biosynthesisCell wall synthesis

Disease associations

InfectionTuberculosis

Safety considerations

Drug resistance

Interacting drugs

Ethambutol

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