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Target intelligence / Profile preview
Arabinosyl transferase EmbB (EmbB)
- Target
- EmbB
- Molecular classification
- Enzyme, Glycosyltransferase, Membrane Protein
01
Overview
Arabinosyl transferase EmbB is an integral membrane protein in Mycobacterium tuberculosis. It is a key enzyme involved in the biosynthesis of arabinogalactan, a critical component of the mycobacterial cell wall. EmbB polymerizes arabinose units and is a target for the first-line anti-tuberculosis drug ethambutol. Mutations in embB are associated with ethambutol resistance.
- Other names
- embB gene productArabinosyltransferase B
02
Mechanism of action
Inhibition of arabinosyltransferase activity, blocking arabinogalactan and lipoarabinomannan synthesis.
03
Biological functions
Arabinose polymerizationArabinogalactan biosynthesisCell wall biosynthesisCell wall organizationCell wall growth
04
Disease associations
InfectionTuberculosis
05
Safety considerations
Ethambutol resistance mutationsEssentiality in Mycobacterium tuberculosis
06
Interacting drugs
Ethambutol (EMB)
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