Archaelysin family metallopeptidase 1 (AMZ1)

Archaelysin family metallopeptidase 1 (AMZ1) is a predicted zinc-dependent metallopeptidase belonging to the metzincin clan, more specifically the archaemetzincin family of metalloproteases[1][2]. It exhibits metal ion binding and proteolytic activity, likely participating in regulated proteolysis. While its precise physiological substrates and roles in humans remain to be experimentally defined, AMZ1 is included in human genomic studies focused on developmental disorders, particularly in a microdeletion region associated with developmental delays and characteristic syndromic features[1]. The broader family of archaemetzincins exhibits a metzincin-type architecture and requires zinc for catalytic function, with a substrate-binding site compatible with broad specificity[1]. No drugs or clinical interventions directly target AMZ1, and its potential roles in disease primarily derive from loss-of-function genetic evidence rather than known catalytic dysfunction or inhibition[1][2].

Other names

Archaemetzincin-1AMZ1KIAA1950Archaebacterial metalloproteinase-like protein 1Metalloproteinase-like proteinArchaemetzincin 1Archeobacterial metalloproteinase-like protein 1