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Target intelligence / Profile preview
Archaelysin family metallopeptidase 2 (AMZ2)
- Target
- AMZ2
- Molecular classification
- Enzyme, Metallopeptidase, Peptidase family M54 (archaemetzincin/archaelysin)
01
Overview
Archaelysin family metallopeptidase 2 (AMZ2) is a zinc-dependent metalloprotease enzyme that displays activity against the peptide angiotensin-3, and is inhibited by amastatin as well as general metallopeptidase inhibitors such as o-phenanthroline and batimastat[1][5][6]. It belongs to the archaemetzincin (archaelysin) family of peptidase (M54) and contains a consensus zinc-binding motif[4]. AMZ2 plays a role in proteolytic processing of peptides and is associated with certain disease phenotypes, including male infertility (specifically globozoospermia), and may contribute to lung tumorigenesis[1][5].
- Other names
- Archaemetzincin-2BM-014Archeobacterial metalloproteinase-like protein 2archaemetzincin-2archaemetzincins-2ESTM12
02
Mechanism of action
Inhibition of zinc metallopeptidase activity (via the above inhibitors)
03
Biological functions
Proteolysis/metallopeptidase activityRegulation of peptide processing
04
Disease associations
Male infertility (due to globozoospermia)Putative role in lung tumorigenesis
05
Interacting drugs
Amastatin (aminopeptidase inhibitor)
2 more in the full profile.
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