Arf-GAP with dual PH domain-containing protein 2 (ADAP2)

Arf-GAP with dual PH domain-containing protein 2 (ADAP2) is an enzyme encoded by the ADAP2 gene in humans and acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor (Arf) family of small GTP-binding proteins. It contains two tandem Pleckstrin Homology (PH) domains, which are capable of binding inositol phospholipids such as PtdInsP3. ADAP2 is believed to function by modulating Arf-mediated signaling pathways through its GAP activity and possibly by regulating lipid signaling via its PH domains. Its detailed physiological and pathological roles remain to be well characterized.

Other names

CENTA2Centaurin-alpha-2centaurin alpha 2 proteincent-bHSA272195arf-GAP with dual PH domain-containing protein 2centaurin beta