ARF GTPase-activating protein 2 (ARFGAP2)

ARF GTPase-activating protein 2 (ARFGAP2) is an enzyme that regulates intracellular signal transduction by accelerating the hydrolysis of GTP bound to ARF family GTPases, thereby converting them from the active (GTP-bound) to inactive (GDP-bound) state[1][4]. ARF GTPases act as molecular switches controlling vesicle formation, membrane trafficking, and actin cytoskeleton dynamics. ARFGAP2 acts as a negative regulator, ensuring proper timing and localization of ARF activity. Dysregulation of this GTPase cycle has been linked to developmental defects, cancer cell migration, and other pathologies related to vesicle transport[1][2][4]. While the protein has not been directly targeted by drugs, its critical roles make it a potential candidate for research into cancer metastasis and other diseases involving cell migration or trafficking dysfunction.

Other names

ARFGAP2ADP-ribosylation factor GTPase-activating protein 2ArfGAP2CGAPKIAA1017

Drugs that would target this class of protein would typically act by: - Inhibiting GTPase-activating function, keeping ARF GTPases in an active state, potentially disrupting membrane trafficking. - Stabilizing or disrupting its interaction with GTPases, thus altering signal output.