ARF GTPase-activating protein GIT2 (GIT2)

ARF GTPase-activating protein GIT2 (GIT2) is a multidomain enzyme belonging to the GIT protein family, acting as a GTPase-activating protein (GAP) for ADP-ribosylation factor (ARF) proteins. GIT2 regulates membrane trafficking, receptor internalization, and focal adhesion turnover through cytoskeletal reorganization, influencing directional cell migration and chemotactic responses. It forms complexes with other proteins (such as PIX) and interacts with paxillin at focal adhesion sites, and is involved in negative regulation of inflammatory pathways and in the cellular response to DNA damage, where it is phosphorylated by ATM kinase and recruited to sites of double-strand breaks. Knockout or deficiency in GIT2 leads to diverse physiological abnormalities, including altered cellular signaling, impaired immune response, and anxiety-like behaviors. Diseases with reported association include some cancers and vascular diseases, although no direct therapeutic targeting or approved drugs for GIT2 are currently recognized.

Other names

KIAA0148CAT-2CAT2PKLCool-interacting tyrosine-phosphorylated protein 2G protein-coupled receptor kinase-interactor 2GRK-interacting protein 2Paxillin kinase linkercool-associated, tyrosine phosphorylated protein 2G protein-coupled receptor kinase interacting ArfGAP 2

Not applicable, as no approved drugs directly targeting GIT2 exist. Its main molecular function is to catalyze the GTP hydrolysis of ARF GTPases, modulating cell signaling pathways