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ARF like GTPase 6 interacting protein 6 (ARL6IP6) is a human gene encoding a protein predicted to interact with ADP-ribosylation factor-like GTPase 6 (ARL6), a member of the ARF family of GTP-binding proteins involved in membrane trafficking. ARL6IP6 itself is predicted to be located at the nuclear inner membrane, but its precise biological functions remain poorly characterized in the literature. While associations with rare diseases such as cutis marmorata telangiectatica congenita and autism spectrum disorder are noted, there is currently no evidence supporting its role as a drug target, and no known drugs, clinical biomarkers, or specific safety concerns are described[5][7][9].
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