Target intelligence / Profile preview

Arginase (ARG)

Target: ARG
Molecular classification: Enzyme, Metalloprotein, Hydrolase

Overview

Arginase is a manganese-dependent metalloenzyme that catalyzes the hydrolysis of L-arginine to L-ornithine and urea. It plays a crucial role in the urea cycle for ammonia detoxification and is also involved in the synthesis of polyamines and proline. Dysregulation of arginase is implicated in various diseases, including hyperargininemia, cardiovascular dysfunction, renal disease, and immune dysregulation. There are two main isoforms: Arginase I (cytoplasmic/liver) and Arginase II (mitochondrial/kidney, etc.).

Other names: L-arginine aminohydrolaseUreohydrolase

Mechanism of action

Hydrolyzes L-arginine to L-ornithine and urea.

Biological functions

Ammonia detoxificationUrea cycleOrnithine synthesisPolyamine synthesisProline synthesisCollagen synthesisWound healingRegulation of intracellular arginine/ornithine levels

Disease associations

HyperargininemiaCardiovascular dysfunctionRenal diseaseImmune dysregulationTumor growthAutoimmune inflammationAsthmaLiver injury

Safety considerations

Excessive inhibition of arginase could disrupt the urea cycle and lead to hyperammonemia.Inhibition may affect nitric oxide production due to competition for L-arginine.

Biomarkers

Elevated Arginase I levels in liver injuryArginase expression in tumors

Beyond the preview

Go deeper on Arginase (ARG).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Arginase (ARG).

Explore the full profile