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Target intelligence / Profile preview
Arginase 1 (ARG1)
- Target
- ARG1
- Molecular classification
- Enzyme, Hydrolase
01
Overview
Arginase 1 (ARG1) is a cytoplasmic enzyme that catalyzes the hydrolysis of L-arginine to L-ornithine and urea, a critical step in the urea cycle for ammonia detoxification. It plays a significant role in immune suppression within the tumor microenvironment and is implicated in skin barrier function. ARG1 is a therapeutic target in cancer and other diseases.
- Other names
- Liver arginaseType I arginase
02
Mechanism of action
Inhibition of arginase activity, restoring arginine levels and anti-tumor immune responses.
03
Biological functions
Urea cycleAmmonia detoxificationPolyamine biosynthesisL-arginine metabolism
04
Disease associations
HyperargininemiaCancerImmune suppressionSkin barrier dysfunctionCardiovascular dysfunction
05
Safety considerations
Potential for off-target effectsImpact on arginine metabolismPotential for immune-related adverse events
06
Interacting drugs
CB-1158
1 more in the full profile.
07
Biomarkers
ARG1 expression levels in tumor microenvironmentArginine levels
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