Target intelligence / Profile preview

Arginase 2 (ARG2)

Target: ARG2
Molecular classification: Enzyme, Hydrolase, Ureohydrolase, Metalloenzyme

Overview

Arginase 2 (ARG2) is a mitochondrial enzyme that catalyzes the hydrolysis of L-arginine to L-ornithine and urea. It is primarily expressed in extra-hepatic tissues, including kidney, prostate, and immune cells. ARG2 plays a role in regulating nitric oxide synthesis, polyamine production, and ammonia detoxification. It has been implicated in cancer, inflammatory diseases, cardiovascular disease, and neurological disorders, making it a potential therapeutic target, particularly in cancer immunotherapy by reversing immunosuppression in the tumor microenvironment.

Other names: Arginase type IIMitochondrial arginase

Mechanism of action

Enzyme inhibition

Biological functions

L-arginine hydrolysisUrea cycle (minor role)Nitric oxide regulationPolyamine biosynthesisAmmonia detoxificationImmune response modulationMacrophage polarization

Disease associations

CancerInflammatory diseasesCardiovascular diseaseNeurological disorders

Safety considerations

Potential for off-target effects due to arginine depletion in non-cancerous tissues.Genetic deletion studies show minimal abnormalities, suggesting a therapeutic window, but careful monitoring is still necessary.

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