Gosset Molecular Classification
Enzyme System, Metabolic Pathway
Disease Roles
Arginine Deiminase System Overview
The arginine deiminase system (ADS) is a metabolic pathway found in various bacteria, where it plays a crucial role in energy production, pH homeostasis, and adaptation to environmental stresses such as acidification. The system catabolizes L-arginine into citrulline and ammonia via arginine deiminase (ADI), ornithine carbamoyltransferase, and carbamate kinase. It generates ATP from ADP during anaerobic conditions and neutralizes acidic environments. ADS is considered a potential antimicrobial/antiparasitic drug target because it is absent in higher eukaryotes.
Mechanism of Action
Inhibition of Arginine Deiminase
Biological Functions
Acid resistance
Energy production
pH homeostasis
Adaptation to environmental stress
Disease Associations
Infection
Biofilm formation
Pathogenicity
Safety Considerations
- Potential disruption of microbial homeostasis