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Arginine Deiminase System (ADS)
- Target
- ADS
- Molecular classification
- Enzyme System, Metabolic Pathway
01
Overview
The arginine deiminase system (ADS) is a metabolic pathway found in various bacteria, where it plays a crucial role in energy production, pH homeostasis, and adaptation to environmental stresses such as acidification. The system catabolizes L-arginine into citrulline and ammonia via arginine deiminase (ADI), ornithine carbamoyltransferase, and carbamate kinase. It generates ATP from ADP during anaerobic conditions and neutralizes acidic environments. ADS is considered a potential antimicrobial/antiparasitic drug target because it is absent in higher eukaryotes.
02
Mechanism of action
Inhibition of Arginine Deiminase
03
Biological functions
Acid resistanceEnergy productionpH homeostasisAdaptation to environmental stress
04
Disease associations
InfectionBiofilm formationPathogenicity
05
Safety considerations
Potential disruption of microbial homeostasis
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