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Target intelligence / Profile preview
Arginine Gingipain (Rgp)
- Target
- Rgp
- Molecular classification
- Enzyme, Cysteine protease, Peptidase family C25
01
Overview
Arginine gingipains are a group of arginine-specific cysteine proteases produced by the bacterium *Porphyromonas gingivalis*, a major pathogen implicated in chronic periodontitis. These enzymes, primarily RgpA and RgpB, are key virulence factors that contribute to bacterial colonization, immune evasion, and tissue destruction in periodontal disease. They are considered therapeutic targets for the treatment of periodontitis.
- Other names
- RgpARgpBArginine-specific cysteine protease
02
Mechanism of action
Inhibition of arginine-specific cysteine protease activity.
03
Biological functions
Tissue degradationImmune modulationAdherence to epithelial cellsHaemagglutinationHaemolysisColonizationNutrient acquisition
04
Disease associations
Chronic periodontitisAlzheimer's disease (potential link)
05
Safety considerations
Potential for off-target effects on other cysteine proteases.Development of resistance by *P. gingivalis*.
06
Interacting drugs
KYT-1 peptide derivatives
2 more in the full profile.
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