Arginine-glutamic acid dipeptide repeats protein (RERE)

Arginine-glutamic acid dipeptide repeats protein (RERE) is a nuclear protein that acts mainly as a transcriptional co-repressor and coregulator, particularly during early development[1][3][5][6]. It belongs to the atrophin family and contains arginine-glutamic acid (RE) dipeptide repeats. RERE co-localizes with transcription factors in the nucleus, regulates gene expression by associating with histone deacetylases, and modulates retinoic acid signaling—critical for normal development of the brain, eye, inner ear, heart, and kidneys[1][2][4][5]. Overexpression of RERE can trigger apoptosis. Mutations in the RERE gene are implicated in neurodevelopmental disorders, including NEDBEH, with features such as intellectual disability, developmental delay, and structural birth defects. RERE is not considered a classic drug target, and no known drugs act directly on it[1][2][3][4][5][6][7].

Other names

ATN1LNEDBEHDNB1ARGARPATN2KIAA0458Atrophin-1-like proteinAtrophin-1-related proteinAtrophin-2