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Target intelligence / Profile preview
Arginine Vasopressin Receptor 1A (V1a)
- Target
- V1a
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
Arginine Vasopressin Receptor 1A (AVPR1A), also known as V1a, is a G-protein coupled receptor that binds to arginine vasopressin. It is widely expressed in the central nervous system and peripheral tissues and plays a crucial role in regulating blood pressure, social behavior, stress response, and cellular functions. Genetic variations in AVPR1A have been associated with autism spectrum disorders, substance abuse vulnerability, and stress vulnerability.
- Other names
- V1a vasopressin receptorAntidiuretic hormone receptor 1ASCCL vasopressin subtype 1a receptorVascular/hepatic-type arginine vasopressin receptor
02
Mechanism of action
Activation of Gq/G11 signaling pathway, leading to increased intracellular calcium levels and activation of protein kinase C.
03
Biological functions
VasoconstrictionSocial behaviorStress responseCell contractionCell proliferationPlatelet aggregationCoagulation factor releaseGlycogenolysisSignal transduction
04
Disease associations
Autism spectrum disorderSubstance abuseStress vulnerability
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