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Target intelligence / Profile preview
Arginine Vasopressin V2 Receptor (AVP-V2R)
- Target
- AVP-V2R
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
The arginine vasopressin V2 receptor (AVP-V2R) is a G protein-coupled receptor primarily located in the kidney collecting ducts. It mediates the antidiuretic effects of arginine vasopressin (AVP), regulating water reabsorption via aquaporin 2 trafficking. Activation increases cAMP, leading to PKA activation and AQP2 translocation to the apical membrane. Mutations in the AVPR2 gene cause nephrogenic diabetes insipidus. The receptor is also implicated in vascular endothelial function and is a therapeutic target for hyponatremia and coagulation disorders.
- Other names
- V2 receptorAVPR2
02
Mechanism of action
Agonism or antagonism of the AVP-V2R, leading to changes in cAMP/PKA signaling and downstream effects on water reabsorption and coagulation factor release.
03
Biological functions
Signal transductionWater reabsorption regulationSalt and urea transport modulationRegulation of coagulation factorsAquaporin 2 trafficking
04
Disease associations
Nephrogenic diabetes insipidusHyponatremiaVon Willebrand diseaseHemophilia A
05
Safety considerations
Overcorrection of hyponatremia with V2 antagonists can lead to osmotic demyelination syndrome.Desmopressin use carries risk of hyponatremia, especially in elderly or patients with underlying kidney dysfunction.
06
Interacting drugs
Desmopressin
1 more in the full profile.
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