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Argininosuccinate Synthase 1 (None)
- Target
- None
- Molecular classification
- Enzyme, Ligase
01
Overview
Argininosuccinate synthase 1 (ASS1) is an enzyme that catalyzes the third step in the urea cycle, converting citrulline and aspartate to argininosuccinic acid. This reaction is crucial for detoxifying ammonia and synthesizing arginine. Mutations in ASS1 cause Citrullinemia Type I, leading to hyperammonemia. In cancer, reduced ASS1 expression results in arginine auxotrophy, making tumor cells vulnerable to arginine-depleting therapies. ASS1 expression can also influence chemotherapy resistance.
02
Mechanism of action
Pegargiminase: Systemic arginine depletion Decitabine: Restores ASS1 expression through demethylation
03
Biological functions
Urea cycleArginine biosynthesisNitric oxide synthesisPolyamine synthesisCreatine synthesisAmmonia detoxification
04
Disease associations
Citrullinemia Type ICancer
05
Safety considerations
Hyperammonemia in Citrullinemia Type IPotential resistance to chemotherapy in cancerArginine auxotrophy in cancer cells
06
Interacting drugs
Pegargiminase
1 more in the full profile.
07
Biomarkers
ASS1 expression level in tumors
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