Argininosuccinate synthetase 1 pseudogene 1 (ASS1P1)

Argininosuccinate synthetase 1 pseudogene 1 (ASS1P1), also known as ASSP1, is a non-coding pseudogene related to the functional argininosuccinate synthase 1 gene (ASS1). It is a non-coding genomic DNA segment that shares high sequence similarity with the functional ASS1 gene but lacks protein-coding potential or known biological activity. Located on chromosome 6p22.3, ASS1P1 (Gene ID: 442167) is officially classified by genomic databases as a pseudogene, meaning it does not produce a functional enzyme or participate in any known metabolic or signaling pathways. The functional ASS1 gene, located on chromosome 9, is protein-coding and involved in the urea cycle. Multiple pseudogenes for ASS1 exist in the human genome, with approximately 10 to 14 copies, often resulting from gene duplication events. Unlike the functional ASS1 gene, the ASS1P1 pseudogene is not implicated in disease, nor is it considered a therapeutic target. No biological function, disease association, drug interaction, or clinical biomarker utility is attributed to ASS1P1, and there is no evidence that it is a misnomer or an incorrect gene symbol, nor does it have clinical or pharmacological relevance.

Other names

ASSP1argininosuccinate synthetase pseudogene 1