Argininosuccinate synthetase 1 pseudogene 12 (ASS1P12)

**Argininosuccinate synthetase 1 pseudogene 12 (ASS1P12)** is a human pseudogene; it is a non-functional DNA segment related by sequence to the protein-coding gene *ASS1* (argininosuccinate synthase 1), but does not encode a functional protein. As a pseudogene, ASS1P12 is not known to have any molecular function, biological role, disease association, or relevance as a therapeutic target. It exists as part of the genome because gene duplications and related processes have produced multiple pseudogenic copies of the functional *ASS1* gene, and these are common in the human genome[3][4][6]. **Key clarification**: ASS1P12 should not be confused with the functional *argininosuccinate synthase 1* enzyme encoded by *ASS1*, which is biologically active in the urea cycle and clinically relevant, especially regarding citrullinemia and cancer metabolism[1][2]. ASS1P12, as a pseudogene, is currently not known to have any biological or therapeutic significance and is not a druggable target.

Other names

ASSP12argininosuccinate synthetase pseudogene 12