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Target intelligence / Profile preview
Argininosuccinate synthetase 1 pseudogene 8 (ASS1P8)
- Target
- ASS1P8
- Molecular classification
- Other (Pseudogene)
01
Overview
Argininosuccinate synthetase 1 pseudogene 8 (ASS1P8) is one of several pseudogenes related to the ASS1 gene. Unlike the functional gene, which encodes the argininosuccinate synthase 1 enzyme responsible for the third step of the urea cycle (combining citrulline and aspartate to form argininosuccinate), ASS1P8 is non-functional and does not produce any active enzyme. There are 10–14 copies of ASS1-related sequences in the human genome, but only the functional gene located on chromosome 9 encodes an active enzyme[4][1][2][3]. Pseudogenes like ASS1P8 generally do not have known clinical or pharmacological significance.
- Other names
- ASSP8
02
Mechanism of action
None; no drugs act via ASS1P8.
03
Biological functions
None; as a pseudogene, ASS1P8 does not encode a functional protein and therefore does not carry out biological activity
04
Disease associations
None; no direct disease association or therapeutic relevance has been described for ASS1P8. The functional gene ASS1 (not the pseudogene ASS1P8) is involved in citrullinemia and cancer metabolism
05
Safety considerations
None; ASS1P8 is not targeted by therapeutics and carries no known safety issues
06
Interacting drugs
None; there are no drugs known to interact with the ASS1P8 pseudogene
07
Biomarkers
None; ASS1P8 is not described as a biomarker
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