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ARL8B pseudogene 2 (ARL8BP2) is a predicted pseudogene in the human genome. It is annotated as a non-protein coding gene closely related to the ARL8B gene, which encodes ARF-like GTPase 8B, a protein involved in lysosomal trafficking and autophagy[3][5]. There is no evidence that ARL8BP2 is expressed as a functional protein or possesses any known biological, therapeutic, or disease role. The absence of relevant functional data and its designation as a pseudogene mean it is not considered a pharmacological or therapeutic target. Key Insights: - The canonical gene, ARL8B, encodes a protein involved in lysosome positioning and autophagy, relevant to neural connectivity and antigen presentation, but ARL8BP2 itself does not encode a functional protein or receptor[1][3][5]. - The term "ARL8BP2" is correct as a pseudogene designation but incorrect if implied to be a receptor, enzyme, or drug target. - No aliases, molecular functions, disease associations, or interacting drugs are reported for ARL8BP2[5]. - If your intention was to target lysosome trafficking or autophagy, ARL8B (not ARL8BP2) is the correct molecule to study.
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