Armadillo-like helical domain-containing protein 4 (ARMH4)

Armadillo-like helical domain-containing protein 4 (ARMH4) is a membrane-associated protein encoded by the ARMH4 gene (also known as C14orf37 and other aliases) on human chromosome 14[2][6]. ARMH4 contains armadillo-like helical repeats, is highly conserved across vertebrates, and is predicted to bind the TORC2 (mTOR complex 2) signaling complex[2][3]. It is expressed dynamically during embryonic development, prominently in the cardiac progenitor fields (first and second heart field) and in various neural tissues in the mouse embryo, with declining expression postnatally[1]. In human studies, ARMH4 is involved in the modulation of immune and inflammatory responses and exerts negative regulatory effects on AKT (via mTORC2/RICTOR interaction) and STAT3 (via IL6ST interaction) signaling pathways[2][5][7]. Although it is associated with some disease processes (e.g., arrhythmogenic right ventricular cardiomyopathy, inflammation, cancer via signaling roles), ARMH4 is not currently a validated therapeutic target and has no known interacting drugs or mechanisms of therapeutic modulation[2][5][7]. It is also considered a specific biomarker for certain cardiomyocyte progenitor populations during heart development[1].

Other names

C14orf37UT2Upstream of mTORC2 proteinupstream of mTORC2c14_5376uncharacterized protein C14orf37