Armadillo repeat-containing protein 1 (ARMC1)

Armadillo repeat-containing protein 1 (ARMC1) is a conserved eukaryotic protein that localizes to both the cytosol and the mitochondrial outer membrane, where it acts as a peripheral component of the mitochondrial contact site and cristae organizing system/mitochondrial intermembrane space bridging complex (MICOS/MIB)[1][3][5]. ARMC1 plays a role in mitochondrial distribution by interacting with protein complexes such as MIRO and MTFR on the mitochondrial outer membrane, participating in processes that affect mitochondrial morphology and movement within the cell[5]. It contains an armadillo repeat domain facilitating protein-protein interactions and a predicted C-terminal heavy-metal-associated domain, suggesting, but not confirming, involvement in metal ion transport or detoxification[2]. While ARMC1 is linked through protein networks and molecular studies with mitochondrial dysfunction, including associations with type 2 diabetes and various cancers, there is no direct evidence of it serving as a therapeutic target, nor are there drugs known to modulate its function[2][4][5]. Knockout of ARMC1 results in altered mitochondrial morphology (fragmented appearance and reduced motility) without major defects in cristae architecture or respiratory function[1][3]. It is not classified as a receptor, enzyme, or transporter, but rather as a structural and regulatory protein within the mitochondrion.

Other names

Armadillo repeat-containing protein 1ARMC1ARCPFLJ10511Arcp

None established for drugs (no known drugs targeting ARMC1)