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Target intelligence / Profile preview
Armadillo repeat-containing protein 2 (ARMC2)
- Target
- ARMC2
- Molecular classification
- ARM-repeat-containing protein family (Armadillo repeat protein), Other (structural protein involved in axonemal complex of cilia/flagella)
01
Overview
ARMC2 encodes a structural protein (~97 kDa in humans) characterized by armadillo (ARM) repeats that form superhelical platforms for protein-protein interaction[3]. The protein is highly conserved among species with motile cilia and flagella, and is essential for the proper assembly and stability of the axonemal central pair complex (CPC), a key microtubule structure in sperm flagellum[1][2][3]. Bi-allelic mutations in ARMC2 are causative of severe sperm flagellum malformations, resulting in male infertility both in humans and animal models[1][2]. In organisms like Chlamydomonas, ARMC2 acts as a cargo adapter for intraflagellar transport (IFT), essential for bringing radial spoke proteins into developing flagella[2]. ARMC2 is not currently a drug target and does not have established biomarkers or associated safety concerns, but it may be implicated in ciliopathies and infertility diagnostics[1][2][4].
- Other names
- ARMC2DKFZp434P0714bA787I22.1SPGF38Armadillo repeat-containing protein 2Armadillo repeat-containing protein 2 (ARMC2)
02
Mechanism of action
Not applicable; no drugs identified targeting this protein
03
Biological functions
Sperm flagellum axoneme organization and functionAssembly and/or stability of the axonemal central pair complex ("CPC")Intraflagellar transport (adapter for cargo transport in cilia/flagella)Protein-protein interactions within flagellar and ciliary assemblyPossibly intracellular signaling and cytoskeletal regulation as part of ARM-repeat protein family
04
Disease associations
Male infertility (especially severe asthenozoospermia and multiple morphological abnormalities of flagella (MMAF))Ciliopathies (disorders of cilia/flagellar function)Chronic obstructive pulmonary disease (COPD; suggested involvement)
05
Safety considerations
Not applicable as there are no drugs or direct therapeutic interventions targeting ARMC2
06
Biomarkers
None validated for patient selection or efficacy; research-level candidate for infertility diagnostics
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