Armadillo repeat-containing protein 5 (ARMC5)

Armadillo repeat-containing protein 5 (ARMC5) is a cytosolic protein in the armadillo/beta-catenin repeat superfamily, notable for containing multiple ARM repeats and a BTB/POZ dimerization domain[1][2][5]. It acts as a substrate-recognition component of a specific E3 ubiquitin ligase complex, participating in the regulation of RNA polymerase II transcription and protein homeostasis[2]. ARMC5 is classified functionally as a tumor suppressor—biallelic inactivation causes or predisposes to primary bilateral macronodular adrenal hyperplasia and a familial tumor syndrome, leading to Cushing syndrome and increased risk of adrenal and meningeal tumors[4][6]. Beyond the adrenal system, it regulates T-cell survival, differentiation (Th1/Th17), and apoptosis, making it relevant for immune function[1]. Loss-of-function mutations are considered pathogenic and are a key biomarker for select adrenal diseases[3][6]. There are currently no known drugs directly targeting ARMC5, likely due to its role as a protein-protein interaction scaffold rather than an enzymatic target[2][5][3].

Other names

Armadillo repeat containing 5ARMC5FLJ13063AIMAH2