Armadillo repeat-containing protein 8 (ARMC8)

Armadillo repeat-containing protein 8 (ARMC8) is a member of the armadillo repeat protein family, characterized by motifs important in protein-protein interactions. It is evolutionarily conserved across vertebrates. ARMC8 is a scaffold protein, not a receptor, enzyme, transporter, or transcription factor, contributing to the CTLH E3 ubiquitin-protein ligase complex. This complex directs selective ubiquitination and degradation of specific substrates, such as the transcription factor HBP1, thus influencing cell proliferation, survival, programmed cell death, cell adhesion, and migration. Its pathways intersect with important signaling networks such as PI3K, Wnt, TGF-β, and NF-κB. While canonical aliases refer to homologous proteins in yeast, ARMC8 does not have a direct ortholog in yeast Gid5/Vid28. Dysregulation of ARMC8 functions is associated with human diseases, including cancer, Marinesco-Sjogren syndrome, and lissencephaly. As of 2025, there are currently no known drugs specifically targeting ARMC8, nor established clinical biomarkers or defined safety issues if targeted therapeutically.

Other names

GID complex subunit 5S863-2HSPC056DKFZP434A043VID28 homolog (S. cerevisiae)VID28armadillo repeat-containing protein 8GID5

No small-molecule drugs identified; ARMC8 functions as part of an E3 ligase complex that mediates ubiquitination and proteasomal degradation