Target intelligence / Profile preview

Aromatase

Molecular classification: Enzyme, Cytochrome P450 superfamily, Monooxygenase

Overview

Aromatase, encoded by the CYP19A1 gene, is a key enzyme in estrogen biosynthesis, converting androgens like testosterone and androstenedione into estrogens such as estradiol and estrone. It plays a critical role in sexual development, reproductive function, and is a therapeutic target in hormone-dependent cancers, particularly breast cancer. Aromatase inhibitors are used to block estrogen synthesis, but their use can have systemic effects, including cardiovascular risks.

Other names: Estrogen synthetaseEstrogen synthase

Mechanism of action

Blocking estrogen synthesis by inhibiting aromatase enzyme activity

Biological functions

Estrogen biosynthesisAndrogen metabolismSexual developmentReproductive functionRegulation of follicle number/developmentDetoxification/removal of excess androgen

Disease associations

Breast cancerEndometrial cancerEndometriosisUterine fibroidsCardiovascular events

Safety considerations

Increased risk for cardiovascular eventsArthralgia/myalgia

Interacting drugs

Aromatase inhibitors

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