Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Aromatase enzyme (None)
- Target
- None
- Molecular classification
- Enzyme, Cytochrome P450 monooxygenase
01
Overview
Aromatase (CYP19A1) is a cytochrome P450 monooxygenase enzyme that catalyzes the conversion of androgens (androstenedione and testosterone) into estrogens (estrone and estradiol). It is essential for estrogen biosynthesis and plays a critical role in sexual development, bone growth, and glucose homeostasis. Aberrant aromatase activity is implicated in various diseases, including aromatase deficiency/excess syndromes and hormone-dependent cancers, making it a key therapeutic target for aromatase inhibitors.
- Other names
- Estrogen synthetaseEstrogen synthaseCytochrome P450 family 19 subfamily A member 1CYP19A1
02
Mechanism of action
Inhibition of estrogen synthesis by blocking the aromatase enzyme.
03
Biological functions
Estrogen biosynthesisSteroid metabolismFemale sexual developmentBone growth regulationGlucose homeostasis regulation
04
Disease associations
Aromatase deficiencyAromatase excess syndromeBreast cancerEndometrial cancerGynecomastiaPrecocious pubertyEndometriosisUterine fibroids
05
Safety considerations
Side effects associated with estrogen deprivation (e.g., bone loss, cardiovascular issues)
06
Interacting drugs
Aromatase inhibitors
Beyond the preview
Go deeper on Aromatase enzyme (None).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Aromatase enzyme (None).