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Target intelligence / Profile preview
Aromatic Amino Acid Decarboxylase (AADC)
- Target
- AADC
- Molecular classification
- Enzyme
01
Overview
Aromatic amino acid decarboxylase (AADC) is a pyridoxal 5′‐phosphate-dependent enzyme that catalyzes the final step in the biosynthesis of several key monoamine neurotransmitters, including dopamine and serotonin. Mutations in the DDC gene cause Aromatic Amino Acid Decarboxylase Deficiency, a rare autosomal recessive neurometabolic disorder.
- Other names
- Aromatic L-amino acid decarboxylase (AADC, AAAD)DOPA decarboxylase (DDC)Tryptophan decarboxylase5-hydroxytryptophan decarboxylase
02
Mechanism of action
Catalyzes the decarboxylation of aromatic L-amino acids to form monoamine neurotransmitters.
03
Biological functions
Neurotransmitter biosynthesisMonoamine neurotransmitter synthesisDopamine synthesisSerotonin synthesisCatalysis
04
Disease associations
Aromatic Amino Acid Decarboxylase DeficiencyNeurometabolic disorder
05
Safety considerations
Limited treatment options for AADC deficiencyVariable efficacy of medications for symptom management
06
Interacting drugs
L-DOPA
2 more in the full profile.
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