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Target intelligence / Profile preview
Aromatic L-amino-acid Decarboxylase (AADC)
- Target
- AADC
- Molecular classification
- Enzyme, Decarboxylase, Pyridoxal phosphate-dependent enzyme
01
Overview
Aromatic L-amino-acid decarboxylase (AADC), also known as DOPA decarboxylase (DDC), is a pyridoxal phosphate-dependent enzyme that catalyzes the decarboxylation of aromatic L-amino acids, including L-DOPA to dopamine and 5-HTP to serotonin. It plays a crucial role in the synthesis of monoamine neurotransmitters and is implicated in AADC deficiency, a rare neurometabolic disorder.
- Other names
- DOPA decarboxylase (DDC)tryptophan decarboxylase5-hydroxytryptophan decarboxylaseDDC
02
Mechanism of action
Catalyzes the decarboxylation of aromatic L-amino acids, converting L-DOPA to dopamine and 5-HTP to serotonin. Also involved in synthesis of trace amines.
03
Biological functions
Neurotransmitter biosynthesis (dopamine, norepinephrine, epinephrine, serotonin)Decarboxylation of aromatic L-amino acidsSynthesis of trace amines (tyramine, tryptamine, phenylethylamine)
04
Disease associations
Neurometabolic disorderAromatic L-Amino Acid Decarboxylase DeficiencyMovement disordersDevelopmental delayAutonomic dysfunctionSleep disturbancesMood disturbances
05
Safety considerations
Varied response to treatment in AADC deficiencyPotential side effects of dopamine agonists and MAO inhibitorsLong-term effects of gene therapy unknown
06
Interacting drugs
L-DOPA
5 more in the full profile.
07
Biomarkers
CSF or plasma levels of dopamine, serotonin, and their metabolitesDDC gene mutations
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