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Target intelligence / Profile preview
ARRDC1 antisense RNA 1 (ARRDC1-AS1)
- Target
- ARRDC1-AS1
- Molecular classification
- Long noncoding RNA (lncRNA), Antisense RNA
01
Overview
ARRDC1 antisense RNA 1 (ARRDC1-AS1) is a long noncoding RNA (lncRNA) transcribed from the antisense strand of the ARRDC1 gene locus on chromosome 9. It does not encode a protein but is classified as an antisense RNA, playing potential regulatory roles in gene expression at the transcriptional and post-transcriptional levels. ARRDC1-AS1 has been shown to be upregulated in glioma tissues and cell lines, where it promotes tumor cell proliferation, migration, and invasion. Its oncogenic function in glioma is mediated by acting as a molecular sponge for miR-432-5p, resulting in upregulation of PRMT5, and its expression is activated by STAT1. There is currently limited functional and clinical information outside of cancer, and no approved drugs target this lncRNA directly.
- Other names
- ARRDC1-AS1C9orf37AD038ARRDC1 antisense gene protein 1
02
Biological functions
Regulation of gene expression (likely post-transcriptional or epigenetic regulation of the sense-strand gene ARRDC1)Oncogenic activity in glioma (via miR-432-5p/PRMT5 axis)Potential regulator of mRNA stability and transcription
03
Disease associations
Cancer (specifically glioma and possibly other tumors)Other
04
Biomarkers
High ARRDC1-AS1 expression is associated with poor prognosis in glioma
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