Arrestin domain-containing protein 2 (ARRDC2)

ARRDC2 (Arrestin domain-containing protein 2) is a member of the alpha-arrestin family, structurally related but functionally distinct from the classical beta-arrestins. ARRDC2 functions as a secondary adaptor protein that partners with E3 ubiquitin ligases (notably NEDD4) to regulate the trafficking and sorting of internalized G protein-coupled receptors (such as the β2-adrenergic receptor) within endosomal compartments, especially promoting their trafficking to a subpopulation of early endosomes rather than mediating endocytosis directly[1][2][4]. ARRDC2 is a mechanosensitive gene strongly induced after mechanical unloading of muscle—particularly in aged muscle—where its overexpression is sufficient to promote muscle atrophy and alter gene expression profiles consistent with disuse atrophy[2][3]. ARRDC2 contains PPxY motifs that mediate interaction with WW domain-containing E3 ligases. While it is not a direct therapeutic drug target or receptor, ARRDC2 may serve as a marker of muscle unloading or atrophy and interact with post-translational regulation pathways, with possible roles in cancer and transcriptional regulation inferred from its protein interactions[2][4]. Summary: ARRDC2 is an alpha-arrestin family adaptor protein involved in endosomal protein trafficking and is a mechanosensitive gene upregulated during muscle unloading and aging. It indirectly contributes to disease processes like muscle atrophy but is not a validated therapeutic drug target, receptor, or enzyme at this time[1][2][3][4].

Other names

ARRDC2PP2703Clone24945arrestin domain-containing protein 2