Arrestin domain-containing protein 5 (ARRDC5)

Arrestin domain-containing protein 5 (ARRDC5) is an alpha-arrestin family adapter protein involved in the regulation of protein transport and endocytosis, as well as spermatogenesis in mammals[1][3][4][5]. It is expressed in testicular germ cells, particularly during the round and elongated spermatid phases, and its loss leads to male sterility without affecting females, establishing it as an essential regulator of sperm maturation[4][5]. ARRDC5 is also implicated in osteoclast differentiation by regulating V-type ATPase localization and bone resorption activity[2]. The protein has been identified as a potential target for non-hormonal male contraception and as a possible prognostic marker in certain cancers, such as lung adenocarcinoma, although its molecular mechanism of action, especially in human disease, is not fully defined[1][3][4].

Other names

Arrestin domain-containing protein 5ARRDC5ARRD5A6NEK1

Not established in drug context. Presumed to act as an E3 ubiquitin ligase adaptor, which could be targeted by molecules modulating ubiquitination or protein transport. Inhibiting ARRDC5 could disrupt sperm maturation, leading to male contraceptive effects.