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Target intelligence / Profile preview
Articular Cartilage
- Molecular classification
- Extracellular matrix, Connective tissue
01
Overview
Articular cartilage is a specialized hyaline cartilage that covers the surfaces of bones in synovial joints. It provides a smooth, low-friction surface for joint movement and acts as a shock absorber, protecting the underlying bone from damage. Its unique composition, including type II collagen and aggrecan, contributes to its load-bearing and compressive properties. However, articular cartilage is avascular, aneural, and alymphatic, resulting in limited regenerative capacity and susceptibility to degenerative conditions like osteoarthritis.
- Other names
- Joint cartilageHyaline articular cartilage
02
Mechanism of action
N/A
03
Biological functions
Load bearingFriction reductionJoint lubricationShock absorptionSmooth articulation
04
Disease associations
OsteoarthritisCartilage degenerationChondral defectsJoint painJoint stiffness
05
Safety considerations
Limited healing capacitySusceptibility to injuryProgressive degeneration with agePoor response to conservative treatmentsRisk of osteoarthritis development
06
Interacting drugs
Hyaluronic acid
4 more in the full profile.
07
Biomarkers
Cartilage oligomeric protein (COMP)Matrix metalloproteinases (MMPs)Collagen fragments (e.g., CTX-II)
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