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Target intelligence / Profile preview
Arylepoxamide Receptor (AEAr)
- Target
- AEAr
- Molecular classification
- G protein-coupled receptor
01
Overview
The arylepoxamide receptor (AEAr) is a novel class of receptor primarily found throughout the brain and spinal cord. It is believed to play a significant role in modulating pain signaling and perception. AEAr represents a novel target for analgesic drug development, distinct from traditional opioid receptors. Recent research suggests that buprenorphine’s unique analgesic properties may be partially mediated through interaction with a mu-opioid receptor subtype now identified as the arylepoxamide receptor.
02
Mechanism of action
Agonism of the arylepoxamide receptor, leading to analgesic effects.
03
Biological functions
Modulation of pain signalingModulation of pain perception
04
Disease associations
Acute painChronic pain
05
Safety considerations
Sedation at higher doses
06
Interacting drugs
SBS-1000
2 more in the full profile.
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