Arylsulfatase F (ARSF)

Arylsulfatase F is a member of the sulfatase enzyme family, specifically the arylsulfatase subfamily, encoded by the ARSF gene on the X chromosome. It catalyzes the hydrolysis of sulfate esters, exhibiting activity toward substrates such as 4-methylumbelliferyl sulfate. Although similar in function to other arylsulfatases, its precise physiological substrate remains less clearly defined. Mutations in ARSF have been associated with conditions such as Martin-Probst syndrome and potentially autism spectrum disorder, though its disease association is less prominent than other sulfatases like arylsulfatase A. There are no approved therapeutic drugs directly targeting Arylsulfatase F, and the enzyme is not a classic biomarker or drug target in current clinical practice. The frequently conflated Arylsulfatase A (ARSA), a related enzyme, is a well-known target for metachromatic leukodystrophy and lysosomal storage disorders but is genetically and functionally distinct from Arylsulfatase F (ARSF).

Other names

Arylsulfatase FARSFARSF_HUMAN

Catalysis of sulfate ester bond hydrolysis in specific substrates (general sulfatase mechanism; no approved drugs specifically targeting ARSF identified)