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Heparan Sulfate Sulfatase
- Molecular classification
- Enzyme, Sulfatase
01
Overview
Heparan sulfate sulfatases are enzymes that remove sulfate groups from heparan sulfate (HS), a highly sulfated polysaccharide found on cell surfaces and in the extracellular matrix. These sulfatases, including SULF1, SULF2, and ARSG, modulate the structure and function of HS, thereby influencing processes like cell signaling, tissue development, immune responses, and tumor progression. They are considered therapeutic targets, especially in cancer and developmental disorders.
- Other names
- SULF1SULF2Arylsulfatase GARSG
02
Mechanism of action
Hydrolyzes O-sulfate esters from glucosamine residues within heparan sulfate chains, modulating its interaction with protein ligands.
03
Biological functions
Regulation of cell signalingExtracellular matrix remodelingModulation of ligand bindingRegulation of angiogenesisRegulation of inflammationHeparan sulfate metabolism
04
Disease associations
Cancer progressionCancer metastasisDevelopmental disordersMucopolysaccharidosesImmune system dysfunctionsNeurodegenerative diseases
05
Safety considerations
Potential for off-target effects due to structural similarity with other sulfatasesAltered heparan sulfate structure can impact various signaling pathways, leading to unforeseen consequences.
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