Arylsulfatase H (ARSH)

Arylsulfatase H (ARSH) is a member of the sulfatase enzyme family, specifically classified as an arylsulfatase, which catalyzes the hydrolysis of sulfate esters from a diverse array of substrates including sulfated steroids, carbohydrates, proteoglycans, and glycolipids[5]. Sulfatase enzymes play crucial roles in regulating hormone metabolism, carbohydrate catabolism, and the degradation of complex molecules involved in cellular and developmental signaling. ARSH, like other sulfatases, is functionally important in lysosomal metabolism, participating in the breakdown of sulfated compounds to maintain cellular homeostasis. While other sulfatases such as arylsulfatase A (ARSA) are directly linked to inherited lysosomal storage diseases, there are currently no well-established disease linkages or clinical biomarker applications described specifically for ARSH. ARSH is considered a therapeutic target due to its classified role as a lysosomal enzyme, but as of now, there are no drugs known to target ARSH directly[5].

Other names

Arylsulfatase HARSHASHsulfatasearylsulfatase H

Catalytic hydrolysis of sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids[5]