ASMTL antisense RNA 1 (ASMTL-AS1)

ASMTL antisense RNA 1 (ASMTL-AS1) is a long non-coding RNA located antisense to the acetylserotonin O-methyltransferase-like gene. It acts as a competing endogenous RNA, binding to specific microRNAs (such as miR-1343-3p or miR-1228-3p) and regulating gene expression in cancer progression. ASMTL-AS1 demonstrates context-dependent functionality, serving as either a tumor suppressor or promoter depending on the cancer type. In hepatocellular carcinoma, it promotes tumor growth and migration by modulating the miR-1343-3p/LAMC1 axis, while in triple-negative breast cancer and thyroid carcinoma it acts as a tumor suppressor by inactivating oncogenic pathways. Its expression level serves as a prognostic marker in several cancers and it is being investigated as a potential therapeutic target[1][2][3].

Other names

CXYorf2NCRNA00105ASMTLASASMTL-ASASMTL antisense RNA 1[3]

Drugs or molecules targeting ASMTL-AS1 would likely function via modulation of its ceRNA activity, altering microRNA (e.g., miR-1343-3p, miR-1228-3p) availability and subsequent target gene expression (e.g., LAMC1, SOX17)[1][2]