Asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog pseudogene

The entry “asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog pseudogene” refers to a **pseudogene** form of the **ALG11** gene. The functional ALG11 gene encodes an enzyme (alpha-1,2-mannosyltransferase) involved in the early steps of N-linked glycosylation, specifically attaching the fourth and fifth mannose residues to the growing lipid-linked oligosaccharide during glycan precursor (LLO) assembly in the ER[1][3]. Mutations in the active ALG11 gene can lead to congenital disorders of glycosylation (ALG11-CDG), a rare, severe multi-system disorder[1]. However, the pseudogene form (as annotated by ENSG00000269651 and LOC100422633) is a **non-functional genomic segment** similar to ALG11 and does **not encode an active protein or enzyme**. Pseudogenes typically do not have biological activity or disease relevance, are not considered therapeutic targets, and do not interact with drugs. This entity should not be considered a valid therapeutic target. **Notes on classification and correctness:** - This entry is a pseudogene, not an active enzyme, receptor, or other targetable protein. - Pseudogenes generally do not produce functional protein and are not therapeutic targets. - The functional ALG11 gene (not the pseudogene) is involved in N-linked glycosylation, but the target in this query is specifically the pseudogene, making it “incorrect” as a target for therapeutic purposes. If information about the functional (protein-coding) version is needed, that would require a separate query specifying only the active ALG11 gene, not the pseudogene.

Other names

ENSG00000269651LOC100422633asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog pseudogene