Gosset Molecular Classification
Enzyme
Disease Roles
Asparagine Synthetase Overview
Asparagine synthetase (ASNS) is an enzyme that catalyzes the ATP-dependent conversion of aspartate and glutamine into asparagine and glutamate. This reaction is essential for cellular nitrogen metabolism and protein biosynthesis. ASNS overexpression promotes proliferation, chemoresistance, and metastasis in some cancers. Tumors with low ASNS expression are more sensitive to L-asparaginase. Inhibition can be achieved through substrate depletion.
Mechanism of Action
Substrate depletion (Aspartate or Glutamine)
Biological Functions
Nitrogen metabolism
Cell growth
Cell proliferation
Protein biosynthesis
Disease Associations
Cancer
Safety Considerations
- Chemoresistance
- Activation of GCN2 kinase pathway
- Unfolded protein response
- Amino acid starvation
Interacting Drugs
L-asparaginase
Associated Biomarkers
| Biomarker |
|---|
| ASNS expression level |