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Aspartate-ammonia ligase (None)
- Target
- None
- Molecular classification
- Enzyme, Ligase
01
Overview
Aspartate-ammonia ligase (also known as asparagine synthetase) catalyzes the ATP-dependent conversion of L-aspartate and ammonia to L-asparagine. It plays a crucial role in asparagine biosynthesis and is implicated in cancer chemotherapy resistance and neurological disorders. Its expression can be upregulated under cellular stress, and mutations can cause asparagine synthetase deficiency, a rare genetic disorder with severe neurological consequences.
- Other names
- Asparagine synthetaseL-Asparagine Synthetase
02
Mechanism of action
Inhibition of asparagine synthesis (indirectly through L-asparaginase depleting asparagine)
03
Biological functions
Amino acid biosynthesisNitrogen metabolismAmino acid metabolismCyanoamino acid metabolism
04
Disease associations
Chemotherapy resistance (leukemia)Asparagine Synthetase Deficiency (ASD)Neurological diseaseCancer
05
Safety considerations
Elevated levels associated with chemotherapy resistanceMutations can cause severe neurological disorders
06
Interacting drugs
L-asparaginase
07
Biomarkers
ASNS expression levels (predictive of L-asparaginase resistance)
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